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Download Basics of Bioinformatics Research – From Idea to Article
Basics of Bioinformatics Research – From Idea to Article video course download, Learn the basics of computer aided drug design and how to publish your first paper from scratch in Bioinformatics. Learn the basics of data analysis for gene expression analysis, molecular docking, visualization of the docked complex, enrichment analysis, microRNA identification production of publication-quality images, writing a research article properly, and using Zotero – a free reference management tool. In this course, you will be getting a proper idea of how a set of genes can can be used to design drugs and how using molecular docking techniques we can validate our results for the best drug.
What you’ll learn
- Perform gene expression analysis
- Create a Protein-protein interaction map and calculate hub genes using Cytoscape
- Screening of potential drug targets
- ADMET analysis of drugs DruLito and OSIRIS
- Perform molecular docking using Autodock Vina
- Visualization of the docked complex using Biovia Discovery Studio
- Enrichment analysis using EnrichR
- Finding microRNAs associated with hub genes using miRNet
- Manuscript preparation and using a bibliographic management tool (Zotero will be used)
- Select a proper journal (Scopus indexed as well as PubMed indexed) for your first paper.
- Uploading a paper to BioRxiv (getting DOI for your first paper)
Course content
- Section 1: Introduction
- Lecture 1 Intro to the course
- Section 2: Study Plan
- Lecture 2 Study Plan
- Section 3: Data analysis and Manipulation
- Lecture 3 Procuring Data
- Lecture 4 Data Manipulation
- Section 4: Finding the Differentially Expressed Genes (DEGs)
- Lecture 5 Creating Venn diagram
- Section 5: Identifying Hub genes from Protein-protein interaction network
- Lecture 6 Creating PPI and using STRING tool and identifying Hub genes using Cytoscape
- Section 6: Identifying drugs associated with hub genes
- Lecture 7 Identification of drugs using Drug gene interaction database (DGIdb)
- Section 7: Screening of drugs
- Lecture 8 Using DruLiTo and OSIRIS for Screening of Drugs
- Section 8: Molecular Docking study
- Lecture 9 Downloading PDB files of proteins
- Lecture 10 UCSF Chimera and AutoDock Vina Installation
- Lecture 11 Energy minimization of protein and preparing the protein for molecular docking
- Lecture 12 Energy minimization of ligand and preparing it for docking
- Lecture 13 Finding pockets for our protein of interest
- Lecture 14 Molecular Docking study
- Lecture 15 Creating the docked complex file
- Lecture 16 Visualization of the docked complex
- Section 9: Producing publication quality images
- Lecture 17 Using Adobe Photoshop for producing images for publication
- Lecture 18 Using Adobe Photoshop for Producing publication quality images
- Section 10: Enrichment analysis
- Lecture 19 Enrichment analysis using Enrichr
- Section 11: Identification of microRNAs associated with top ten hub genes
- Lecture 20 Using miRNet for identification of microRNAs associated with top ten hub genes
- Section 12: Writing your first paper
- Lecture 21 Anatomy of a research article and selection of correct journal
- Lecture 22 Preparing manuscript for journal and using Zotero for reference management
- Lecture 23 Uploading your manuscript to BioRxiv
- Section 13: Course Conclusion
- Lecture 24 Course Conclusion
Who this course is for:
- Anyone interested in any branch of life science
- Aspiring researchers
- Anyone who wants to know how a drug discovery process looks like
- Anyone interested in in-silico research
- Anyone who want to learn computer aided drug design
- Anyone interested in learning molecular docking
- Anyone interested in bioinformatics
Course details
- Video quality: MP4 | Video: h264, 1280 × 720
- Audio quality: Audio: AAC, 44.1 KHz, 2 Ch
- Video duration: 3h 24m
- Update: 05/2022
- Number of lessons: 13 sections, 24 lectures
- Language: English
- File size: 2.15 GB
