Download Schrodinger Suites 2023-4 Build 132 x64

Schrodinger Suites 2023-4 windows, linux and macOS version download with full crack Software is an excellent software for molecular docking studies. Schrödinger develops state-of-the-art chemical simulation software for use in pharmaceutical, biotechnology, and materials research. Their physics based computational platform leverages a deep understanding of physics, chemistry, and predictive modeling to accelerate innovation in drug discovery. This allows collaborators to discover high-quality, novel molecules more rapidly, at lower cost, and most likely with a higher likelihood of success compared to traditional methods.

It is the most complete and advanced simulation software for chemical engineering and materials science. This program can implement the most accurate molecular simulations and has a wide range of applications in various sciences including medicine, pharmacy, materials and chemistry. There are few engineers who have not used Schrodinger software. The software is named after Erwin Schrodinger, an Austrian physicist with his latest and most complete atomic theory.

The theory of quantum mechanics is also the result of his tireless efforts, which is why the Schrodinger Science Foundation named the most powerful atomic simulation software after this great scientist.
This program generally consists of 5 sections: Small-Molecule Drug Discovery Suite, Materials Science Suite, Discovery Informatics Suite, PyMOL, Jaguar and Biologics Suite, each of which includes a large number of independent programs; The Schrödinger Suite collection includes all the software of these 5 sections and, in short, has all the software produced by this company and is applicable to all sciences.

With Schrodinger Suites software, chemical engineers can study and simulate new polymer and chemical structures, study different reactions, and monitor everything at the atomic dimension. With the help of this software, materials engineers can study the crystal structures of materials and extract various properties such as mechanical, thermal, optical, chemical, etc., and can also simulate new alloys and apply them in complex environments such as temperature. Study high, corrosive and so on. With this software, pharmacists can simulate new drugs and study their effects, study the molecular structure and DNA, and make new drugs.

Key features of Schrodinger Suites software:

  • The most complete and advanced software for simulating materials at the atomic and molecular scale
  • Performing the most complex simulations of pharmaceutical, crystalline, polymeric and chemical materials
  • Simulation of reactivity of new and modern materials
  • Simulation of material application in sensitive environments such as high temperature
  • Simulation of different properties of materials such as mechanical properties
  • Study of atomic theory and quantum mechanics and perform physical calculations
  •  Extensive user in pharmaceutical sciences and simulation of new drugs
  • Ability to automate data analysis and calculations

What's new in 2023.3 release

Lead Optimization

  • Fit torsions on the fly via FFBuilder for FEP+ Web Services [2023-3]
  • Support linker enumeration of compounds with symmetrical R-groups [2023-3]

Constant pH Simulations

  • Full-featured release of constant pH simulations [2023-3]
  • Improved analysis of constant pH simulations for protein pKa calculations [2023-3]
  • Automatically write constant pH trajectories specific to each pH
  • View trajectories from lambda dynamics calculations such as those from the constant pH workflow

Solubility FEP

  • Fit torsions on the fly via FFBuilder for FEP+ Web Services [2023-3]

Quantum Mechanics

  • Predict conformation-dependent IR and VCD/ECD spectra using an automated workflow within the new Jaguar Spectroscopy product [2023-3]
  • Download importable Jaguar-formatted basis sets from Basis Set Exchange [2023-3]
  • Access dynamic scans from the Relaxed Scan panel [2023-3]
  • Access the ΔSCF method and a script to prepare ΔSCF input on the command line [2023-3]

Semi-Empirical Quantum Mechanics

  • Parallelize batch and individual xTB calculations with OpenMP [2023-3]

Hit Identification & Virtual Screening

Ligand Preparation
Empirical and QM-based pKa Prediction

  • Benefit from improved accuracy with the addition of several hundred more data points in the Macro-pKa training set [2023-3]

Active Learning Applications

  • Adjust equilibration simulation times and complex restraint options in Active Learning-FEP [2023-3]
  • Connect to ongoing GraphDB runs when restarting Active Learning-FEP jobs [2023-3]
  • Generate a final Maestro file that contains all ligands with FEP data and the corresponding endpoints [2023-3]

Shape Screening

  • Screen up to tens of billions of compounds quickly and efficiently with the new Quick Shape ligand-based screening workflow [2023-3]


  • Fit torsions on the fly via FFBuilder for FEP+ Web Services [2023-3]

Target Validation & Structure Enablement

Protein Preparation

  • Optionally use custom PFAM databases in [2023-3]
  • Import structures into Coot with standard residue names from protein preparation’s PDB output. The Maestro output retains protonation-specific residue naming, i.e HIP/HID/HIE instead of HIS [2023-3]
  • Significantly improved performance of Protein Preparation including the Interactive Optimizer for systems of 90,000 atoms or more [2023-3]

Multiple Sequence Viewer/Editor

  • Benefit from speed and accuracy improvements in protein/nucleic acid structure alignment from replacing the previous SKA aligner with the CEAlign algorithm [2023-3]
  • Download structural models directly from AlphaFold2 by providing a UniProt ID [2023-3]


  • Design out common ADMET liabilities using the new IFD-MD workflow (Beta). Predict complex structures of a ligand bound to CYP2D6, CYP3A4, PXR, or hERG [2023-3]

Platform Environment
Maestro Graphical Interface

  • Apply ribbon and cartoon styling on selected entries [2023-3]
  • Improve visualization of interactions crossing Periodic Boundary Conditions [2023-3]
  • Seamlessly copy and paste data from the Project Table into external applications including spreadsheets, enabling efficient data transfer and analysis [2023-3]
  • Trajectory Player [2023-3]
  • View trajectories from lambda dynamics calculations such as those from the constant pH workflow
  • Navigate frames in trajectory visualization easily using keyboard arrow keys
    3D Builder [2023-3]
  • Access Builder Behavior options from the 3D Builder palette
  • Interactively mutate native nucleotides in the Workspace, including between DNA to RNA and RNA to DNA nucleotides [2023-3]
  • Enhanced “Save Project As” functionality with Windows-only UX improvements [2023-3]
  • Maestro to PyMOL connection [2023-3]
  • Streamline the integration of WaterMaps with PyMOL
  • Include Maestro Scene “Description” as a PyMOL Message for better scene management
    Maestro to LiveDesign connection [2023-3]
  • Seamlessly integrate between Maestro and LiveDesign with the new Mapping Manager.
  • Easily rename property mappings and eliminate the issue of cluttered names when creating variations. Save and share mappings using the direct import and export feature.

Job Control

  • Smart distribution jobs in Job Server now check license availability, eliminating risk of license exhaustion [2023-3]

Workflows & Pipelining [KNIME Extensions]

  • Streamline the login process with the LiveDesign connection node using Single Sign-On (SSO) tokens [2023-3]

Schrodinger Suites software detail:

  • Operating system: Windows 10 & 11 x64, Linux x64 and macOS
  • File Size: 18.4 GB + 10.1 GB + 8.1 GB
  • Crack: Full crack (unlimited system)
4.9/5 - (55 votes)

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