Download An Introduction to Drug Synthesis by Graham Patrick

An Introduction to Drug Synthesis Illustrated Edition by Graham L. Patrick pdf download explores the central role played by organic synthesis in the process of drug design and development. Written by an experienced and talented author to complement his existing An Introduction to Medicinal Chemistry.

the book illustrates how organic synthesis makes important contributions throughout the drug design and discovery process – from the generation of novel drug structures to the improved efficiency of large scale synthesis. Avoiding excessively detailsed descriptions of the underlying synthetic pathways, the book focuses on how synthesis can be used in a strategic way – how and why different synthetic approaches are adopted, and the pros and cons of each.

With examples used extensively to illustrate the concepts presented, An Introduction to Drug Synthesis is the ideal resource for any pharmaceutical or medicinal chemistry student who needs a thorough understanding of how the concepts of organic synthesis are applied to the development of therapeutic drugs.

Table of Contents

  • PART A Concepts
  • 1 The drug discovery process
  • 2 Drug synthesis
  • 3 Retrosynthesis
  • 4 Cyclic systems in drug synthesis
  • 5 The synthesis of chiral drugs
  • 6 Combinatorial and parallel synthesis
  • PART B Applications of drug synthesis in the drug development process
  • 7 Synthesis of lead compounds
  • 8 Analogue synthesis in drug design
  • 9 Synthesis of natural products and their analogues
  • 10 Chemical and process development
  • 11 Synthesis of isotopically labelled compounds
  • PART C Design and synthesis of selected antibacterial agents
  • 12 Design and synthesis of tetracyclines
  • 13 Erythromycin and macrolide antibacterial agents
  • 14 Quinolones and fluoroquinolones
  • Appendix 1 Functional group
  • transformations
  • Appendix 2 Functionalization
  • Appendix 3 Removal of functional groups
  • Appendix 4 Coupling reactions involving carbon–heteroatom bond formation
  • Appendix 5 Coupling reactions involving carbon–carbon bond formation
  • Appendix 6 Protecting groups
  • Appendix 7 Structures of amino acids
  • Glossary
  • Index

eBook details

  • Author (s): Graham Patrick
  • Year of publication: 2015
  • Publisher:  Oxford University Press; Illustrated edition
  • Writing language: English
  • ISBN: 9780198708438,  9780191073472, 0191073474
  • Number of pages: 587 pages
  • Book format: True PDF
  •  File size: 15.5 MB
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